Dysplastic Nevus with Eruptive Melanocytic Lesions That Developed during Nilotinib Therapy for Chronic Myeloid Leukemia
نویسندگان
چکیده
782 Ann Dermatol Received May 12, 2014, Revised February 16, 2015, Accepted for publication February 25, 2015 Corresponding author: Hyun Jeong Park, Department of Dermatology, Yeouido St. Mary’s Hospital, The Catholic University of Korea, College of Medicine, 10 63-ro, Yeongdeungpo-gu, Seoul 07345, Korea. Tel: 82-2-3779-1230, Fax: 82-2-783-7604, E-mail: [email protected] This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http:// creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. Fig. 1. Dermoscopic picture showing structureless pigmentation with asymmetric and irregular and fuzzy borders, and several blackish globules. http://dx.doi.org/10.5021/ad.2015.27.6.782
منابع مشابه
Coexistence of BCR-ABL1 Translocation and JAK2 V617F Mutation in a Patient with Chronic Myeloid Leukemia Under Long-term Treatment with Imatinib and Nilotinib: A Case Report
This report describes an 89-year-old woman diagnosed with Philadelphia positive Chronic Myeloid Leukemia in 2007 who was initially treated with 200 mg/day imatinib. The patient demonstrated complete molecular response (CMR) in two tests in 2015 and 2018. During treatment between 2007 and 2019, despite increased dosage of imatinib and switching her therapy to nilotinib, complete hematological r...
متن کاملSpot diagnosis: eruptive melanocytic naevi during azathioprine therapy in Crohn's disease.
igure 1 Endoscopic image of the sole showing multiple lightrown to black coloured moles. Long term use of thiopurines in the treatment of inflammatory bowel disease (IBD) is associated with the development of non-melanoma skin cancer. Here we present a patient who developed unusual skin abnormalities during azathioprine administration. A 22-year-old woman with known Crohn's disease (located at ...
متن کاملExpression of cyclooxygenase-2 in melanocytic skin lesions by immunohistochemistry
Introduction: cyclooxygenase-2 (COX-2) is involved in pathogenesis of various tumors and possibly malignant skin tumors including malignant melanoma; however, there is not enough information about COX-2 expression in benign melanocytic lesions. In the present study we compared the expression levels of COX-2 in malignant melanoma and benign melanocytic lesions. Method: In this analytical study, ...
متن کاملMyeloid leukemia-1 expression in benign and malignant melanocytic lesions.
Myeloid leukemia-1 (Mcl-1) is an anti-apoptotic protein implicated in tumor progression. Its expression was found to be elevated in many types of human cancers and is correlated with tumor progression. The expression of Mcl-1 in melanoma is not fully understood. We investigated the expression of Mcl-1 in normal nevi, dysplastic nevi, primary melanoma and melanoma metastases by tissue microarray...
متن کاملAgminated melanocytic nevus status post dabrafenib therapy for metastatic melanoma.
Agminated melanocytic nevus is an uncommon type of mole, characterized by a local group of macular or papular pigmented lesions, well demarcated, without a common pigmented background. This pattern has also been associated with Spitz nevi, dysplastic melanocytic nevi, and non-melanocytic lesions.We describe the onset of an acquired agminated melanocytic nevus after dabrafenib treatment. Our cas...
متن کامل